Technology Platform

Cellular and Molecular Imaging Technology Platform

The application of MRI Imaging Technology (Magnetic Resonance Imaging, MRI)

is becoming more and more popular in diagnostic imaging medicine, and it has been growing rapidly in recent years.  MRI images are non-invasive medical images, and are commonly used for early diagnosis of various diseases, such as cancer, multiple sclerosis, brain degeneration, and senile spine tuberculosis.  Its range of application has become broader and broader with the development of instruments and imaging technology.  Our company developed a new contrast agent (IOP Injection) with PEG surface modified iron oxide nanoparticles to calibrate cells.  After cell transplantation, MRI is used to track the distribution, movement, and location of cells.  This can allow scientists and doctors to keep track of the movement and safety of the cells after transplantation.  In addition, IOP Injection can also be used for immune cell labeling, including T-lymphocytes, macrophages, and dendritic cells.  IOP Injection can also specifically calibrate internal T-cells, providing very good cell-level MRI tracking images, which makes great contributions to future regenerative medicine and inflammatory diseases.



Nano Graft Technology Platform

Nano grafting technology

Nano-graft reaction is to combine nano-particles and modifiers through chemical reaction to change the surface structure and state of nano-particles to achieve the purpose of surface denaturation. Nano-grafting technology occupies an extremely important position in the surface modification of nano-particles. Due to the fact that nano particles are larger than its surface area, the surface bond state and electronic state are different from the interior of the particles, and the incomplete coordination leads to the existence of a large number of bonding groups, which also provides favorable conditions for surface modification of nanoparticles. Surface chemical modification methods can be roughly divided into

1. Coupling agents: Inorganic nanoparticles are generally incompatible with organic materials commonly used for surface modification, so usually the help of coupling agent is required.  Coupling agents usually require two functional groups that can react with the surface of nanoparticles and can react with organic modifiers.  For instance, as of organo-silane (XR-Si (OR) 3), X is an organic functional group, one of the most representative types of coupling agents.

2. Esterification: The reaction between nanoparticles and alcohols is an esterification reaction. The esterification reaction can change the hydrophilic and hydrophobic properties of the surface of nanoparticles.

3.Polymerization graft modification: The use of chemical polymerization to graft polymers to the surface of nanoparticles to achieve the purpose of surface modification. The polymerization grafting method can be divided into.

    (1) The initiator initiates the direct polymerization of monomers into polymer chains on the surface of nanoparticles.

    (2) The use of chemical reactions to link polymer links to the surface of the particles.

The surface modification method can effectively improve or change the dispersion, weather resistance, durability and surface activity of nanoparticles, so that nanoparticles can produce new physical, chemical and optical properties to adapt to different application requirements.